Heat shock proteins and their use as anticancer vaccines.
نویسندگان
چکیده
Giorgio Parmiani, Alessandro Testori, Michele Maio, Chiara Castelli, Licia Rivoltini, Lorenzo Pilla, Filiberto Belli, Vincenzo Mazzaferro, Jorgelina Coppa, Roberto Patuzzo, Mario R. Sertoli, Axel Hoos, Pramod K. Srivastava, and Mario Santinami Istituto Nazionale Tumori and European Institute of Oncology, Milan, Italy; University of Siena, Siena, and Istituto Scientifico Tumori, Genoa, Italy; and Antigenics, Inc., New York, NY; and University of Connecticut, Farmington, Connecticut
منابع مشابه
Heat Shock Proteins Enriched-Promastigotes of Leishmania major Inducing Th2 Immune Response in BALB/c Mice
Background: Heat shock proteins (HSP) are highly conserved molecules with many immunological functions. They are highly immunogenic with important role in cancer immunotherapy and in vaccine development against infectious diseases. As adjuvant, HSP can augment the immunogenicity of weak antigens and can stimulate antigen presenting cells. Although vaccines have been successful for many infec...
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Although the use of tumor-derived heat shock/chaperone proteins (HSPs) as anticancer vaccines is gaining wider study and acceptance, there have thus far been no reports concerning chaperone antitumor activities against disseminated hematological malignancies. We have devised an efficient and effective method for purification of the chaperone proteins grp94/gp96, HSP90, HSP70, and calreticulin f...
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Heat shock proteins (HSPs) have been linked to the therapy of both cancer and inflammatory diseases, approaches that utilize contrasting immune properties of these proteins. It would appear that HSP family members Hsp60 and Hsp70, whether from external sources or induced locally during inflammation, can be processed by antigen-presenting cells and that HSP-derived epitopes then activate regulat...
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ورودعنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 10 24 شماره
صفحات -
تاریخ انتشار 2004